/*******************************************************************************
* GenPlay, Einstein Genome Analyzer
* Copyright (C) 2009, 2014 Albert Einstein College of Medicine
*
* This program is free software: you can redistribute it and/or modify
* it under the terms of the GNU General Public License as published by
* the Free Software Foundation, either version 3 of the License, or
* (at your option) any later version.
*
* This program is distributed in the hope that it will be useful,
* but WITHOUT ANY WARRANTY; without even the implied warranty of
* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
* GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with this program. If not, see <http://www.gnu.org/licenses/>.
* Authors: Julien Lajugie <julien.lajugie@einstein.yu.edu>
* Nicolas Fourel <nicolas.fourel@einstein.yu.edu>
* Eric Bouhassira <eric.bouhassira@einstein.yu.edu>
*
* Website: <http://genplay.einstein.yu.edu>
******************************************************************************/
package edu.yu.einstein.genplay.core.operation.SCWList;
import java.util.ArrayList;
import java.util.Collection;
import java.util.concurrent.Callable;
import edu.yu.einstein.genplay.core.manager.project.ProjectChromosomes;
import edu.yu.einstein.genplay.core.manager.project.ProjectManager;
import edu.yu.einstein.genplay.core.operation.Operation;
import edu.yu.einstein.genplay.core.operationPool.OperationPool;
import edu.yu.einstein.genplay.dataStructure.chromosome.Chromosome;
import edu.yu.einstein.genplay.dataStructure.list.genomeWideList.SCWList.SCWList;
import edu.yu.einstein.genplay.dataStructure.list.genomeWideList.SCWList.SCWListBuilder;
import edu.yu.einstein.genplay.dataStructure.list.listView.ListView;
import edu.yu.einstein.genplay.dataStructure.scoredChromosomeWindow.ScoredChromosomeWindow;
/**
* Computes a Standard Score normalization on a {@link SCWList}
* @author Julien Lajugie
*/
public class SCWLONormalizeStandardScore implements Operation<SCWList> {
private final SCWList scwList; // input list
private boolean stopped = false; // true if the operation must be stopped
/**
* Creates an instance of {@link SCWLONormalizeStandardScore}
* @param scwList input list
*/
public SCWLONormalizeStandardScore(SCWList scwList) {
this.scwList = scwList;
}
@Override
public SCWList compute() throws Exception {
// compute average
final double avg = scwList.getStatistics().getAverage();
// compute standard deviation
final double stdev = scwList.getStatistics().getStandardDeviation();
ProjectChromosomes projectChromosomes = ProjectManager.getInstance().getProjectChromosomes();
final OperationPool op = OperationPool.getInstance();
final Collection<Callable<Void>> threadList = new ArrayList<Callable<Void>>();
final SCWListBuilder resultListBuilder = new SCWListBuilder(scwList);
for (final Chromosome chromosome: projectChromosomes) {
final ListView<ScoredChromosomeWindow> currentList = scwList.get(chromosome);
Callable<Void> currentThread = new Callable<Void>() {
@Override
public Void call() throws Exception {
if (currentList != null) {
for (int j = 0; (j < currentList.size()) && !stopped; j++) {
int start = currentList.get(j).getStart();
int stop = currentList.get(j).getStop();
// apply the standard score formula: (x - avg) / stdev
float score = (float) ((currentList.get(j).getScore() - avg) / stdev);
resultListBuilder.addElementToBuild(chromosome, start, stop, score);
}
}
// tell the operation pool that a chromosome is done
op.notifyDone();
return null;
}
};
threadList.add(currentThread);
}
op.startPool(threadList);
return resultListBuilder.getSCWList();
}
@Override
public String getDescription() {
return "Operation: Normalize, Standard Score";
}
@Override
public String getProcessingDescription() {
return "Normalizing";
}
@Override
public int getStepCount() {
return 1 + scwList.getCreationStepCount();
}
@Override
public void stop() {
stopped = true;
}
}