/* * BioJava development code * * This code may be freely distributed and modified under the * terms of the GNU Lesser General Public Licence. This should * be distributed with the code. If you do not have a copy, * see: * * http://www.gnu.org/copyleft/lesser.html * * Copyright for this code is held jointly by the individual * authors. These should be listed in @author doc comments. * * For more information on the BioJava project and its aims, * or to join the biojava-l mailing list, visit the home page * at: * * http://www.biojava.org/ * * Created on June 24, 2010 * Author: Mark Chapman */ package org.biojava.nbio.alignment; import org.biojava.nbio.core.alignment.SimpleSequencePair; import org.biojava.nbio.alignment.template.AbstractPairwiseSequenceAligner; import org.biojava.nbio.core.alignment.template.AlignedSequence; import org.biojava.nbio.core.alignment.template.AlignedSequence.Step; import org.biojava.nbio.alignment.template.GapPenalty; import org.biojava.nbio.core.alignment.template.SubstitutionMatrix; import org.biojava.nbio.core.sequence.template.Compound; import org.biojava.nbio.core.sequence.template.Sequence; import java.util.List; /** * Smith and Waterman defined an algorithm for pairwise local sequence alignments (best match of sections from each * {@link Sequence}). This class performs such local sequence comparisons efficiently by dynamic programming. * * @author Mark Chapman * @param <S> each {@link Sequence} of the alignment pair is of type S * @param <C> each element of an {@link AlignedSequence} is a {@link Compound} of type C */ public class SmithWaterman<S extends Sequence<C>, C extends Compound> extends AbstractPairwiseSequenceAligner<S, C> { /** * Before running a pairwise local sequence alignment, data must be sent in via calls to * {@link #setQuery(Sequence)}, {@link #setTarget(Sequence)}, {@link #setGapPenalty(GapPenalty)}, and * {@link #setSubstitutionMatrix(SubstitutionMatrix)}. */ public SmithWaterman() { super(null, null, null, null, true); } /** * Prepares for a pairwise local sequence alignment. * * @param query the first {@link Sequence} of the pair to align * @param target the second {@link Sequence} of the pair to align * @param gapPenalty the gap penalties used during alignment * @param subMatrix the set of substitution scores used during alignment */ public SmithWaterman(S query, S target, GapPenalty gapPenalty, SubstitutionMatrix<C> subMatrix) { super(query, target, gapPenalty, subMatrix, true); } // method for AbstractMatrixAligner @Override protected void setProfile(List<Step> sx, List<Step> sy) { profile = pair = new SimpleSequencePair<S, C>(getQuery(), getTarget(), sx, xyStart[0], getQuery().getLength() - xyMax[0], sy, xyStart[1], getTarget().getLength() - xyMax[1]); } }