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package org.broad.igv.plugin.mongovariant;
import com.mongodb.WriteResult;
import junit.framework.Assert;
import org.broad.igv.AbstractHeadlessTest;
import org.broad.igv.util.ResourceLocator;
import org.broad.igv.variant.Allele;
import org.broad.igv.variant.vcf.VCFVariant;
import org.broadinstitute.gatk.tools.walkers.na12878kb.core.MongoVariantContext;
import org.broadinstitute.gatk.tools.walkers.na12878kb.core.NA12878DBArgumentCollection;
import org.broadinstitute.gatk.tools.walkers.na12878kb.core.NA12878KnowledgeBase;
import org.broadinstitute.gatk.tools.walkers.na12878kb.core.TruthStatus;
import htsjdk.variant.variantcontext.VariantContext;
import htsjdk.variant.variantcontext.VariantContextBuilder;
import org.junit.Assume;
import org.junit.Before;
import org.junit.Ignore;
import org.junit.Test;
import java.io.IOException;
import java.util.Arrays;
import java.util.Iterator;
import java.util.List;
import static org.junit.Assert.*;
/**
* Test retrieving variants from mongo database.
* This test requires that the relevant mongo db be running,
* so we ignore it because we can't be sure about foreign conditions.
* <p/>
* User: jacob
* Date: 2012-Dec-14
*/
@Ignore("Test only intended to be run manually")
public class VariantReviewTest extends AbstractHeadlessTest {
String dbSpecPath = "resources/NA12878kb_local.json";
private int allele0 = 0;
private int allele1 = 1;
private String callsetName = "test_callset";
private TruthStatus truthStatus = TruthStatus.SUSPECT;
private String chr = VariantReviewSource.chromoNameToStandard("chr10");
//0-based coords
private int start = (int) 1e6;
private int end = start + 1;
private List<String> alleles = Arrays.asList("A", "G");
private MongoVariantContext mvc;
private VariantReviewSource source;
@Before
public void setUp() throws Exception {
super.setUp();
VariantContextBuilder builder = new VariantContextBuilder();
//Convert from exclusive end to inclusive end
builder.start(start + 1).stop(end).chr(chr).alleles(alleles);
VariantContext vc = builder.make();
mvc = VariantReviewSource.createMVC(allele0, allele1, callsetName, vc, truthStatus, false);
int errorsResetting = 0;
try {
errorsResetting = resetDB();
} catch (Exception e) {
System.out.println(e);
Assume.assumeNoException(e);
}
Assume.assumeTrue(errorsResetting == 0);
source = new VariantReviewSource(new ResourceLocator(dbSpecPath));
}
@Override
public void tearDown() throws Exception {
super.tearDown();
try {
resetDB();
} catch (Exception e) {
e.printStackTrace();
}
}
private boolean checkFeatureNotPresent() throws Exception {
Iterator<VCFVariant> result = getFeature();
return !result.hasNext();
}
/*
* Basically here to check the remove call
*/
@Test
public void testFeatureNotPresent() throws Exception {
boolean featNotPresent = checkFeatureNotPresent();
if (!featNotPresent) {
Iterator<VCFVariant> result = getFeature();
while (result.hasNext()) {
System.out.println(result.next());
}
}
assertTrue(featNotPresent);
}
//TODO Separate into add/get methods, but that requires prepopulation of data
@Test
public void testAddGetFeature() throws Exception {
source.consensusOnly = false;
Assume.assumeTrue(checkFeatureNotPresent());
String errorMessage = VariantReviewDialog.addCall(dbSpecPath, mvc);
if (errorMessage != null) System.out.println(errorMessage);
assertNull(errorMessage);
Iterator<VCFVariant> result = getFeature();
Assert.assertTrue("Empty result after adding call", result.hasNext());
VCFVariant variant = result.next();
Assert.assertFalse("Empty result after adding call", result.hasNext());
assertEquals(chr, variant.getChr());
assertEquals(start, variant.getStart());
assertEquals(end, variant.getEnd());
assertEquals(alleles.get(0), variant.getReference().replace("*", ""));
int index = 1;
for (Allele al : variant.getAlternateAlleles()) {
assertEquals(alleles.get(index++), al.toString());
}
assertTrue(variant.getSource().equals(callsetName));
}
private Iterator<VCFVariant> getFeature() throws IOException {
return source.getFeatures(chr, start, end);
}
private int resetDB() throws Exception {
NA12878DBArgumentCollection args = new NA12878DBArgumentCollection(dbSpecPath);
NA12878KnowledgeBase kb = new NA12878KnowledgeBase(null, args);
List<WriteResult> writeResults = kb.removeCall(mvc);
kb.close();
int errCount = 0;
for (WriteResult wr : writeResults) {
if (wr.getError() != null) {
System.out.println(wr.getError());
errCount++;
}
}
return errCount;
}
}