/* * #%L * org.gitools.matrix * %% * Copyright (C) 2013 - 2016 Universitat Pompeu Fabra - Biomedical Genomics group * %% * This program is free software: you can redistribute it and/or modify * it under the terms of the GNU General Public License as * published by the Free Software Foundation, either version 3 of the * License, or (at your option) any later version. * * This program is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU General Public License for more details. * * You should have received a copy of the GNU General Public * License along with this program. If not, see * <http://www.gnu.org/licenses/gpl-3.0.html>. * #L% */ package org.gitools.matrix.transform; import org.gitools.api.ApplicationContext; import org.gitools.api.analysis.IAggregator; import org.gitools.api.analysis.IProgressMonitor; import org.gitools.api.matrix.*; import org.gitools.matrix.model.MatrixLayer; import org.gitools.matrix.model.MatrixLayers; import org.gitools.matrix.model.hashmatrix.HashMatrix; import org.gitools.matrix.model.hashmatrix.HashMatrixDimension; import org.gitools.matrix.model.iterable.PositionMapping; import org.gitools.matrix.sort.AggregationFunction; import org.gitools.matrix.transform.parameters.AggregatorParameter; import org.gitools.matrix.transform.parameters.DimensionParameter; import org.gitools.utils.aggregation.MeanAggregator; import org.gitools.utils.aggregation.MedianAggregator; import static org.gitools.api.matrix.MatrixDimensionKey.COLUMNS; import static org.gitools.api.matrix.MatrixDimensionKey.ROWS; public class FoldChangeFunction extends ConfigurableTransformFunction { public static final String AGGREGATION_PARAM = "Aggregation"; AggregatorParameter aggregatorParameter; public static final String DIMENSION_PARAM = "Dimension"; DimensionParameter dimensionParameter; private IMatrixLayer aggLayer; private final static Key<HashMatrix> CACHEKEY = new Key<HashMatrix>() {}; private IMatrixLayer newLayer; private IProgressMonitor monitor; private HashMatrix data; public FoldChangeFunction(IMatrixLayer newLayer) { super("Fold-Change"); this.newLayer = newLayer; } @Override public Double apply(Double value, IMatrixPosition position) { if(value != null) { Double mean = getMedian(position.get(MatrixDimensionKey.ROWS)); if (mean == null) { return null; } return value - mean; } return null; } @Override public void onBeforeIterate(IMatrixIterable<Double> parentIterable) { super.onBeforeIterate(parentIterable); monitor = ApplicationContext.getProgressMonitor().subtask(); IMatrix matrix = parentIterable.getPosition().getMatrix(); IMatrixDimension transformDimension = matrix.getDimension(dimensionParameter.getParameterValue()); IMatrixDimension aggDimension = matrix.getDimension(COLUMNS == dimensionParameter.getParameterValue() ? ROWS : COLUMNS); IAggregator aggregator = aggregatorParameter.getParameterValue(); AggregationFunction aggregationFunction = new AggregationFunction(newLayer, aggregator, aggDimension); IMatrixLayer aggLayer = new MatrixLayer("agg", Double.class); HashMatrix aggregationMatrix = new HashMatrix( new MatrixLayers(aggLayer), new HashMatrixDimension(ROWS, matrix.getRows()) ); matrix.newPosition() .iterate(transformDimension) .monitor(monitor.subtask(), "Preparing for '" + this.name + "' transformation") .transform(aggregationFunction) .store( aggregationMatrix, new PositionMapping().map(matrix.getRows(), ROWS), aggLayer ); monitor.end(); newLayer.setCache(CACHEKEY, aggregationMatrix); } private Double getMedian(String identifier) { if (data == null) { data = (HashMatrix) newLayer.getCache(CACHEKEY); aggLayer = data.getLayers().get(0); } return (Double) data.get(aggLayer, identifier); } @Override public FoldChangeFunction createNew() { return new FoldChangeFunction(newLayer); } @Override protected void createDefaultParameters() { dimensionParameter = new DimensionParameter(); dimensionParameter.setDescription("Select if the fold change should be relative to the rows or columns dimension"); dimensionParameter.setChoices(MatrixDimensionKey.values()); addParameter(DIMENSION_PARAM, dimensionParameter); aggregatorParameter = new AggregatorParameter(); aggregatorParameter.setDescription("Select if the fold change should be calculated with the row/column median or mean"); IAggregator[] iAggregators = { MedianAggregator.INSTANCE, MeanAggregator.INSTANCE }; aggregatorParameter.setChoices(iAggregators); addParameter(AGGREGATION_PARAM, aggregatorParameter); } public String getName() { return aggregatorParameter.getParameterValue().toString() + " " + dimensionParameter.getParameterValue().getLabel() + " fold-change"; } public String getDescription() { return "Fold change calculated relative to the " + aggregatorParameter.getParameterValue().toString() + " of each " + dimensionParameter.getParameterValue().getLabel(); } }